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Haematologic Technologies

代理公司介绍:haemtech

域名名字里 单词拆分 haem(血红素)tech(科技),

Haematologic (血液学),也就说这家公司的产品都是人体血液相关蛋白以及抗体

Haematologic Technologies公司是一家专门致力于高质量的人血浆蛋白的分离和特性研究、生产及高通量上等抗体的行业***,公司产品主要用于体外研究。该公司核心产品包括凝血级联反应以及骨代谢调控相关蛋白,全部产品线包括150多种高纯度、高性能的蛋白产品,具体有酶原、酶、协同因子、底物和抑制剂、样品收集管及抗凝管等。除高纯蛋白产品外,Haematologic Technologies是世界上*大的单克隆抗体和蛋白生产商之一,通过利用染色体组/蛋白质组的方法开发抗体,公司可提供上万种单/多克隆抗体,力求针对每一个人类表达基因开发至少一种抗体产品。此外,公司还提供部分技术服务,如:蛋白定制、纯化、修饰检测、定制生产与科研合作等。

公司使命:为全球凝血研究领域提供高品质的高纯高活性蛋白及相关试剂,同时持续改进我们的蛋白生产和质控标准,以及通过挖掘内部潜力及与血栓/止血研究领域的**研究机构和企业进行战略合作以确保公司前沿领军地位。

公司核心竞争力:Haematologic Technologies通过以下三方面优势从众多竞争者中脱颖而出:上等的技术服务、智力资源、定制生产与研究。上等的技术服务部是公司的*大优势,可为使用本公司产品的客户提供****的服务,为客户提供完善的实验设计、实验方法及常见问题等方面的详尽建议,使使用产品的科学家无形中参与公司产品的生产和研发。

公司主要产品系列:

一、人血浆产品系列:

该产品系列包括凝血因子及抑制剂、血小板和骨代谢调控相关蛋白质。

1、酶原:包括:Factor VII、Factor IX、Factor X、Factor X (修饰)、Factor XI、Factor XII、Factor XIII、glu-Plasminogen、lys-Plasminogen、Protein C、Prothrombin。

2、酶类:包括:、Activated Protein C*、Thrombin (alpha)*、Thrombin (beta, gamma)、Factor VIIa、Factor IXa*、Factor Xa* (gla-domainless available)、Factor XIa、Factor XIIIa、Plasmin、(*可提供封闭活性位点产品)。

3、辅酶因子:包括:Factor V、Factor Va、Fibronectin、Protein S、von Willebrand Factor(vWF)、von Willebrand Factor (无VIII 因子)、Thrombomodulin (兔)、Protein Z。

4、蛋白酶抑制剂:包括:Antithrombin III、Heparin Cofactor II、TAFI、Angiostatin、Alpha-2-Plasmin Inhibitor。

5、蛇毒蛋白酶:包括:RVV-X Activator、RVV-V Activator、E. Carinatus II Protease

6、人血小板和其它血浆蛋白产品:包括:Fibrinogen & Fragments、Beta-2-Glycoprotein-1、Human Platelet Osteonectin、Platelet Factor 4、Beta-Thromboglobulin、Thrombospondin、Vitronectin、Recombinant Tissue Factor

7、骨相关蛋白酶:Osteocalcin

二、牛血浆产品系列:

该产品系列包括凝血因子及抑制剂、血小板和骨代谢调控相关蛋白质。

1、酶原:包括:Bovine Factor IX、Bovine Factor X、Bovine Plasminogen、Bovine Protein C、Bovine Prothrombin。

2、酶类:包括:Bovine Activated Protein C、Bovine Thrombin、Bovine Factor IXa、Bovine Factor Xa,均可提供封闭活性位点产品。

3、辅酶因子:包括:Bovine Factor V、Bovine Factor Va。

4、骨代谢相关蛋白:Osteocalcin。

5、蛇毒蛋白酶:包括RVV-X Activator、RVV-V Activator及E. Carinatus II Protease。

6、新产品:Bovine Lactadherin

三、小鼠血浆产品系列:

1、酶原:包括:Mouse Factor X、Mouse Plasminogen、Mouse Prothrombin、Mouse Prothrombin Frag-1 (please call)、Mouse Prethrombin-2 (please call)。

2、酶类:包括:Mouse Thrombin、Mouse Factor Xa、Mouse Plasmin。

3、部分血液蛋白相关抗体:

(1)单克隆抗体:包括:Rat anti-Mouse Protein C、Rat anti-Mouse Prothrombin Rat anti-Mouse Plasminogen、Rat anti-Mouse Factor X、Rat anti-Mouse Factor VIII。

(2)多克隆抗体:包括:Sheep anti-Mouse Factor X、Sheep anti-Mouse Factor X - Immuno Adsorbed、Sheep anti-Mouse Prothrombin、Sheep anti-Mouse Plasminogen、Sheep anti-Mouse Protein C、Sheep anti-Mouse ATIII、Sheep anti-Mouse Fibrinogen、Sheep anti-Rat Factor IX。

4、其它产品:Mouse Antithrombin III、Mouse Fibrinogen、Rat Factor IX (please call)、Rat Factor IXa (please call)、Rat Factor X (please call)、Rat Thrombin (please call)、Rat Prethrombin-2 (please call)、Rat Fibrinogen (please call)、Rabbit Thrombomodulin。

四、抑制剂产品系列:

1、氯基甲酮产品:包括:FPR-chloromethylketone (PPACK)、EGR-chloromethylketone (GGACK)、Biotinylated EGR-chloromethylketone、Fluorescein EGR-chloromethylketone、Biotinylated FPR-chloromethylketone、Fluorescein FPR-chloromethylketone。

  2、人蛋白酶抑制剂:Antithrombin III、Heparin Cofactor II、TAFI、Angiostatin、Alpha-2-Plasmin Inhibitor。

3、其它产品:包括玉米胰蛋白酶抑制剂(CTI)和DAPA。

品牌链接:http://www.shijichina.com/goodsid/ziliaoview/271640.html

Haematologic Technologies,Haematologic Technologies代理,Haematologic Technologies销售,Haematologic Technologies公司,Haematologic Technologies产品,Haematologic Technologies价格

部分列表

| HCVII-0030    | Human Factor VII                                 |     | Haematologic Technologies |

| ABOC-5021     | Anti-Bovine Osteocalcin                          |     | Haematologic Technologies |

| ABV-5103      | Anti-Bovine Factor V                             |     | Haematologic Technologies |

| ABV-5104      | Anti-Bovine Factor V                             |     | Haematologic Technologies |

| ABV-5105      | Anti-Bovine Factor V                             |     | Haematologic Technologies |

| ABV-5106      | Anti-Bovine Factor V                             |     | Haematologic Technologies |

| ABV-5107      | Anti-Bovine Factor V                             |     | Haematologic Technologies |

| ABX-5051      | Anti-Bovine Factor X                             |     | Haematologic Technologies |

| AHIX-5041     | Anti-Human Factor IX                             |     | Haematologic Technologies |

| AHP-5013      | Anti-Human Prothrombin                           |     | Haematologic Technologies |

| AHPC-5011     | Anti-Human Protein C                             |     | Haematologic Technologies |

| AHPC-5071     | Anti-Human Protein C                             |     | Haematologic Technologies |

| AHPC-5072     | Anti-Human Protein C                             |     | Haematologic Technologies |

| AHPS-5091     | Anti-Human Protein S                             |     | Haematologic Technologies |

| AHPS-5092     | Anti-Human Protein S                             |     | Haematologic Technologies |

| AHT-5020      | Anti-Human Thrombin                              |     | Haematologic Technologies |

| AHTF-5264     | Anti-Human Tissue Factor                         |     | Haematologic Technologies |

| AHTFPI-5138   | Anti-Human Tissue Factor Pathway Inhibitor       |     | Haematologic Technologies |

| AHV-5101      | Anti-Human Factor V                              |     | Haematologic Technologies |

| AHV-5102      | Anti-Human Factor V                              |     | Haematologic Technologies |

| AHV-5108      | Anti-Human Factor V                              |     | Haematologic Technologies |

| AHV-5110      | Anti-Human Factor V                              |     | Haematologic Technologies |

| AHV-5112      | Anti-Human Factor V                              |     | Haematologic Technologies |

| AHV-5146      | Anti-Human Factor V                              |     | Haematologic Technologies |

| AHVII-5031    | Anti-Human Factor VII                            |     | Haematologic Technologies |

| AHVIII-5025   | Anti-Human Factor VIII                           |     | Haematologic Technologies |

| AHX-5050      | Anti-Human Factor X                              |     | Haematologic Technologies |

| AHXI-5061     | Anti-Human Factor XI                             |     | Haematologic Technologies |

| AHXII-5155    | Anti-Human Factor XII                            |     | Haematologic Technologies |

| AMP-9013      | Rat anti-Mouse Prothrombin                       |     | Haematologic Technologies |

| AMPC-9071     | Rat anti-Mouse Protein C                         |     | Haematologic Technologies |

| AMPC-9072     | Rat anti-Mouse Protein C                         |     | Haematologic Technologies |

| AMPG-9130     | Rat anti-Mouse Plasminogen                       |     | Haematologic Technologies |

| AMVII-9031    | Anti-Mouse Factor VII                            |     | Haematologic Technologies |

| AMVIII-9035   | Anti-Mouse Factor VIII                           |     | Haematologic Technologies |

| AMX-9050      | Rat Anti-Mouse Factor X                          |     | Haematologic Technologies |

| AMX-9051      | Rat Anti-Mouse Factor X                          |     | Haematologic Technologies |

| ANG-01        | Angiostatin                                      |     | Haematologic Technologies |

| AON-5031      | Anti-Human Osteonectin                           |     | Haematologic Technologies |

| B2GI-0001     | β2 Glycoprotein I                               |     | Haematologic Technologies |

| BCAPC-1080    | Bovine APC                                       |     | Haematologic Technologies |

| BCAPC-DEGR    | Bovine APC-DEGR                                  |     | Haematologic Technologies |

| BCIX-1040     | Bovine Factor IX                                 |     | Haematologic Technologies |

| BCIXA-1050    | Bovine Factor IXa                                |     | Haematologic Technologies |

| BCIXA-DEGR    | Bovine Factor IXa-DEGR                           |     | Haematologic Technologies |

| BCIXA-EGR     | Bovine Factor IXa-EGR                            |     | Haematologic Technologies |

| BCP-1010      | Bovine Prothrombin                               |     | Haematologic Technologies |

| BCPC-1070     | Bovine Protein C                                 |     | Haematologic Technologies |

| BCPG-1130     | Bovine Plasminogen                               |     | Haematologic Technologies |

| BCT-1020      | Bovine α-thrombin                               |     | Haematologic Technologies |

| BCT-BFPRCK    | Bovine α-thrombin-BFPRCK                        |     | Haematologic Technologies |

| BCT-DFP       | Bovine α-thrombin-DFP                           |     | Haematologic Technologies |

| BCT-FPRCK     | Bovine α-thrombin-FPRCK                         |     | Haematologic Technologies |

| BCV-1100      | Bovine Factor V                                  |     | Haematologic Technologies |

| BCVA-1110     | Bovine Factor Va                                 |     | Haematologic Technologies |

| BCX-1050      | Bovine Factor X                                  |     | Haematologic Technologies |

| BCXA-1060     | Bovine Factor Xa                                 |     | Haematologic Technologies |

| BCXA-DEGR     | Bovine Factor Xa-DEGR                            |     | Haematologic Technologies |

| BCXA-EGR      | Bovine Factor Xa-EGR                             |     | Haematologic Technologies |

| BEGRCK-06     | Biotinylated EGR-chloromethylketone              |     | Haematologic Technologies |

| BFPRCK-06     | Biotinylated FPR-chloromethylketone              |     | Haematologic Technologies |

| BLAC-1200     | Bovine Lactadherin                               |     | Haematologic Technologies |

| BLAC-FITC     | FITC-conjugated Bovine Lactadherin (1.6 uM)      |     | Haematologic Technologies |

| BOC-3020      | Bovine Osteocalcin                               |     | Haematologic Technologies |

| BON-3010      | Bovine Osteonectin                               |     | Haematologic Technologies |

| CTI-01        | Corn Trypsin Inhibitor                           |     | Haematologic Technologies |

| DAPA          | dansylarginine-N-                                |     | Haematologic Technologies |

| ECVVII-2011   | E. Carinatus II Protease                         |     | Haematologic Technologies |

| EGRCK-01      | Glu-Gly-Arg-chloromethylketone                   |     | Haematologic Technologies |

| FEGRCK-06     | Fluorescein EGR-chloromethylketone               |     | Haematologic Technologies |

| FFPRCK-06     | Fluorescein FPR-chloromethylketone               |     | Haematologic Technologies |

| FPRCK-01      | Phe-Pro-Arg-chloromethylketone                   |     | Haematologic Technologies |

| HA2AP-0230    | Human α-2 Plasmin Inhibitor                     |     | Haematologic Technologies |

| HBTG-0210     | Human β-Thromboglobulin                         |     | Haematologic Technologies |

| HCAPC-0080    | Human APC                                        |     | Haematologic Technologies |

| HCAPC-DEGR    | Human APC-DEGR                                   |     | Haematologic Technologies |

| HCATIII-0120  | Human Antithrombin III                           |     | Haematologic Technologies |

| HCBT-0022     | Human b-thrombin                                 |     | Haematologic Technologies |

| HCBXA-0061    | Human β-Factor Xa                               |     | Haematologic Technologies |

| HCFN-0170     | Human Fibronectin                                |     | Haematologic Technologies |

| HCGT-0021     | Human g-thrombin                                 |     | Haematologic Technologies |

| HCI-0150D     | Human Fibrinogen Fragment D                      |     | Haematologic Technologies |

| HCI-0150E     | Human Fibrinogen Fragment E                      |     | Haematologic Technologies |

| HCI-0150R     | Human Fibrinogen                                 |     | Haematologic Technologies |

| HCII-0190     | Human Heparin Cofactor II                        |     | Haematologic Technologies |

| HCIX-0040     | Human Factor IX                                  |     | Haematologic Technologies |

| HCIXA-0050    | Human Factor IXa                                 |     | Haematologic Technologies |

| HCIXA-DEGR    | Human Factor IXa-DEGR                            |     | Haematologic Technologies |

| HCIXA-EGR     | Human Factor IXa-EGR                             |     | Haematologic Technologies |

| HCP-0010      | Human Prothrombin                                |     | Haematologic Technologies |

| HCP1-0010     | Human Prothrombin Fragment 1                     |     | Haematologic Technologies |

| HCP1-0011     | Human Prethrombin-1                              |     | Haematologic Technologies |

| HCP12-0010    | Human Prothrombin Fragment 1 - 2                 |     | Haematologic Technologies |

| HCP2-0010     | Human Prothrombin Fragment 2                     |     | Haematologic Technologies |

| HCP2-0011     | Human Prethrombin-2                              |     | Haematologic Technologies |

| HCPC-0070     | Human Protein C                                  |     | Haematologic Technologies |

| HCPG-0130     | Human glu-Plasminogen                            |     | Haematologic Technologies |

| HCPG-0131     | Human glu-Plasminogen (affinity form I)          |     | Haematologic Technologies |

| HCPG-0132     | Human glu-Plasminogen (affinity form II)         |     | Haematologic Technologies |

| HCPG-0133     | Human lys-Plasminogen                            |     | Haematologic Technologies |

| HCPM-0140     | Human Plasmin                                    |     | Haematologic Technologies |

| HCPS-0090     | Human Protein S                                  |     | Haematologic Technologies |

| HCPZ-0220     | Human Protein Z                                  |     | Haematologic Technologies |

| HCT-0020      | Human α-thrombin                                |     | Haematologic Technologies |

| HCT-BFPRCK    | Human α-thrombin-BFPRCK                         |     | Haematologic Technologies |

| HCT-DFP       | Human α-thrombin-DFP                            |     | Haematologic Technologies |

| HCT-FPRCK     | Human α-thrombin-FPRCK                          |     | Haematologic Technologies |

| HCTP-0200     | Human Thrombospondin                             |     | Haematologic Technologies |

| HCV-0100      | Human Factor V                                   |     | Haematologic Technologies |

| HCVA-0110     | Human Factor Va                                  |     | Haematologic Technologies |

| HCVIIA-0031   | Human Factor VIIa                                |     | Haematologic Technologies |

| HCVWF-0190    | Human von Willebrand Factor                      |     | Haematologic Technologies |

| HCVWF-0191    | Human von Willebrand Factor (Factor VIII free)   |     | Haematologic Technologies |

| HCX-0050      | Human Factor X                                   |     | Haematologic Technologies |

| HCXA-0060     | Human Factor Xa                                  |     | Haematologic Technologies |

| HCXA-BEGR     | Human Factor Xa-BEGR                             |     | Haematologic Technologies |

| HCXA-DEGR     | Human Factor Xa-DEGR                             |     | Haematologic Technologies |

| HCXA-EGR      | Human Factor Xa-EGR                              |     | Haematologic Technologies |

| HCXA-GD       | Human Gla-Domainless β-Factor Xa                |     | Haematologic Technologies |

| HCX-GD        | Human Gla-domainless Factor X                    |     | Haematologic Technologies |

| HCXI-0150     | Human Factor XI                                  |     | Haematologic Technologies |

| HCXIA-0160    | Human Factor XIa                                 |     | Haematologic Technologies |

| HCXII-0155    | Human Factor XII                                 |     | Haematologic Technologies |

| HCXIII-0160   | Human Factor XIII                                |     | Haematologic Technologies |

| HCXIIIA-0165  | Human Factor XIIIa                               |     | Haematologic Technologies |

| HOC-0302      | Human Osteocalcin                                |     | Haematologic Technologies |

| HON-0303      | Human Osteonectin                                |     | Haematologic Technologies |

| HPF4-0180     | Human Platelet Factor 4                          |     | Haematologic Technologies |

| HVN-0230      | Human Vitronectin                                |     | Haematologic Technologies |

| MCAPC-5080    | Mouse APC                                        |     | Haematologic Technologies |

| MCATIII-5120  | Mouse Antithrombin III                           |     | Haematologic Technologies |

| MCI-5150      | Mouse Fibrinogen                                 |     | Haematologic Technologies |

| MCIX-5040     | Mouse Factor IX                                  |     | Haematologic Technologies |

| MCIXA-5050    | Mouse Factor IXa                                 |     | Haematologic Technologies |

| MCP-5010      | Mouse Prothrombin                                |     | Haematologic Technologies |

| MCPC-5070     | Mouse Protein C                                  |     | Haematologic Technologies |

| MCPG-5130     | Mouse Plasminogen                                |     | Haematologic Technologies |

| MCPM-5140     | Mouse Plasmin                                    |     | Haematologic Technologies |

| MCT-5020      | Mouse Thrombin                                   |     | Haematologic Technologies |

| MCX-5050      | Mouse Factor X                                   |     | Haematologic Technologies |

| MCXA-5060     | Mouse Factor Xa                                  |     | Haematologic Technologies |

| PABFV-S       | Sheep anti-Human Factor V                        |     | Haematologic Technologies |

| PAHAT-S       | Sheep anti-Human Antithrombin III                |     | Haematologic Technologies |

| PAHCII-S      | Sheep anti-Heparin Cofactor II                   |     | Haematologic Technologies |

| PAHF4-RAB     | Rabbit anti-Human Platelet Factor 4              |     | Haematologic Technologies |

| PAHFII-BU     | Burro anti-Human Prothrombin                     |     | Haematologic Technologies |

| PAHFII-S      | Sheep anti-Human Prothrombin                     |     | Haematologic Technologies |

| PAHFII-SAP    | Sheep anti-Human Prothrombin, Affinity Purified  |     | Haematologic Technologies |

| PAHFIX-C      | Chicken anti-Human Factor IX                     |     | Haematologic Technologies |

| PAHFIX-S      | Sheep anti-Human Factor IX                       |     | Haematologic Technologies |

| PAHFIX-SAP    | Sheep anti-Human Factor IX, Affinity Purified    |     | Haematologic Technologies |

| PAHFVA-S      | Sheep anti-Human Factor Va                       |     | Haematologic Technologies |

| PAHFV-H       | Horse anti-Human Factor V                        |     | Haematologic Technologies |

| PAHFVIIA-RAB  | Rabbit anti-Human Factor VIIa                    |     | Haematologic Technologies |

| PAHFVIII-S    | Sheep anti-Human Factor VIII                     |     | Haematologic Technologies |

| PAHFVII-S     | Sheep anti-Human Factor VII                      |     | Haematologic Technologies |

| PAHFV-S       | Sheep anti-Human Factor V                        |     | Haematologic Technologies |

| PAHFXIII-S    | Sheep anti-Human Factor XIII                     |     | Haematologic Technologies |

| PAHFXII-S     | Sheep anti-Human Factor XII                      |     | Haematologic Technologies |

| PAHFXI-S      | Sheep anti-Human Factor XI                       |     | Haematologic Technologies |

| PAHFXI-SAP    | Sheep anti-Human Factor XI, Affinity Purified    |     | Haematologic Technologies |

| PAHFX-S       | Sheep anti-Human Factor X                        |     | Haematologic Technologies |

| PAHPC-C       | Chicken anti-Human Protein C                     |     | Haematologic Technologies |

| PAHPC-H       | Horse anti-Human Protein C                       |     | Haematologic Technologies |

| PAHPC-S       | Sheep anti-Human Protein C                       |     | Haematologic Technologies |

| PAHPG-S       | Sheep anti-Human Plasminogen                     |     | Haematologic Technologies |

| PAHPS-S       | Sheep anti-Human Protein S                       |     | Haematologic Technologies |

| PAHPZ-S       | Sheep anti-Human Protein Z                       |     | Haematologic Technologies |

| PAHTFPI-S     | Sheep anti-Human Tissue Factor Pathway Inhibitor |     | Haematologic Technologies |

| PAHTF-S       | Sheep anti-Human Tissue Factor                   |     | Haematologic Technologies |

| PAHT-S        | Sheep anti-Human Thrombin                        |     | Haematologic Technologies |

| PAHVWF-S      | Sheep anti-Human vWF                             |     | Haematologic Technologies |

| PAMFII-S      | Sheep anti-Mouse Prothrombin                     |     | Haematologic Technologies |

| PAMFX-S       | Sheep anti-Murine Factor X                       |     | Haematologic Technologies |

| PAMFX-SIA     | Sheep anti-Murine Factor X - Immuno adsorbed     |     | Haematologic Technologies |

| PAMPC-S       | Sheep anti-Murine Protein C                      |     | Haematologic Technologies |

| PAMPG-S       | Sheep anti-Mouse Plasminogen                     |     | Haematologic Technologies |

| PAPFGN-S      | Sheep anti-Porcine Fibrinogen                    |     | Haematologic Technologies |

| PATAFI-S      | Sheep anti-Human TAFI                            |     | Haematologic Technologies |

| RABTM-4202    | Rabbit Thrombomodulin                            |     | Haematologic Technologies |

| RTF-0300      | Recombinant Tissue Factor                        |     | Haematologic Technologies |

| RVVV-2000     | RVV-V Activator                                  |     | Haematologic Technologies |

| RVVX-2010     | RVV-X Activator                                  |     | Haematologic Technologies |

| SCAT-27-4.5/5 | CTI/Citrate Blood Collection Tube                |     | Haematologic Technologies |

| TAFI-01       | Thrombin-Activatable Fibrinolysis Inhibitor      |     | Haematologic Technologies |

Haematologic Technologies 中国代理, Haematologic Technologies 上海代理, Haematologic Technologies 北京代理,Haematologic Technologies 广东代理, Haematologic Technologies 江苏代理Haematologic Technologies 湖北代理,Haematologic Technologies 天津,Haematologic Technologies黑龙江代理,Haematologic Technologies 内蒙古代理,Haematologic Technologies 吉林代理,Haematologic Technologies 福建代理, Haematologic Technologies 江苏代理, Haematologic Technologies 浙江代理,Haematologic Technologies 四川代理,


Haematologic Technologies Inc. (HTI) 公司是一家专门致力于高质量的人血浆蛋白的分离和特性研究的重要生产商, 其产品非常适用于体内研究。在公司发展的**个十年里,HTI将目光投向参与血液凝集和纤维蛋白溶解,以及骨代谢调节的蛋白的研究。HTI产品系列含有* 过100种高纯度和特异性的蛋白,包括:酶原、酶、协同因子和抑制剂,同时还提供补体系列的单克隆和多克隆抗体。另外,HTI还提供一些技术服务,如:蛋 白定制、纯化、修饰、科研合作等。


Human Coagulation Factor XIIIa

人凝血因子XIIIa

纤维蛋白

的稳定可溶性纤维蛋白转化为不溶性纤维蛋白凝块由转座酰胺酶XIIIa催化。纤维蛋白的α-和γ-链的赖氨酸和谷氨酰胺侧链交联以形成均聚物。


HCXIIIA-0165 人体因子XIIIa

尺寸 50μg

公式 50%甘油/ 500uM EDTA(v / v)

存储 -20℃下

纯度 > 95%通过SDS-PAGE

活动确定 光度测定

保质期(妥善储存) 12个月


样品凝胶信息:

凝胶 Novex 4-12%Bis-Tris

加载 人因子XIIIa,每泳道1μg

缓冲 MOPS

标准 SeeBluePlus 2; 肌球蛋白(191kDa),磷酸化酶B(97kDa),BSA(64kDa),谷氨酸脱氢酶(51kDa),醇脱氢酶(39kDa),碳酸酐酶(28kDa),肌红蛋白红(19kDa),溶菌酶kDa的)

特别说明 在未还原的样品中,A链在活化后朝向B链向下移动。

概述

因子XIIIa(FXIIIa)(纤维蛋白溶血素,血浆转谷氨酰胺酶,纤维蛋白稳定因子,EC 2.3.2.13)是在凝血级联的*后阶段起作用的谷氨酰胺酰基γ-谷氨酰转移酶,通过交联α和γ链稳定纤维蛋白凝块的纤维蛋白以形成均聚物(1-4)。FXIIIa的几个独特功能使其与通常与之相关的蛋白质分开。因子XIIIa是凝血级联的**非蛋白水解酶。与其他转座酰胺酶不同,它完全以酶原形式存在,是**在细胞外起作用的巯基酶。

血浆FXIIIa是由2对不相同亚基(A2B2)(4-7)组成的四聚体(Mr = 312,000)。血小板FXIII是二聚体(Mr = 46,000),仅由一对相同的A亚基(A2)组成,如来自所有细胞内源的因子XIII(7-11)。A亚基含有6个游离的巯基,其中之一是活性中心(12)。

血浆FXIII(A2B2)转化为活性转谷氨酰胺酶FXIIIa(A2')是由A亚基(13)的NH2-末端的Arg36-Gly37肽键的凝血酶催化水解产生的。由该切割诱导的构象变化导致活性位点半胱氨酸的暴露。完全活性仅在B亚基二聚体从A2'二聚体(14-16)的Ca2 +依赖性(Kd = 10-3M)解离之后才实现。通过结合含有Aa链残基242-424(14-16)的纤维蛋白(ogen)区域,可增强A2'B2复合物的解离。因此,在FXIII(90nM),纤维蛋白原(8μM)和Ca 2+(2.5mM游离)的正常血浆浓度下,产生的所有FXIIIa将处于完全活化(A2')分子形式。由FXIIIa产生的其他与生理相关的交联复合物包括纤维蛋白纤维蛋白原(17),纤维蛋白 - 纤连蛋白(18),纤维蛋白-vWF(19),纤维蛋白-α2-抗血纤蛋白(20),纤维蛋白 - 肌动蛋白(21),纤维蛋白 - 血小板反应蛋白纤连蛋白胶原(19),vWF胶原(19),肌动蛋白肌球蛋白(21,22),因子V因子V(23)。除了凝块稳定之外,FXIIIa被认为在涉及细胞增殖的各种过程中起作用,例如伤口**,组织重塑,动脉粥样硬化和肿瘤生长。

血浆FXIIIa通过α-淀粉酶在EDTA存在下裂解均质血浆FXIII产生。通过离子和亲和层析纯化A2'B2亚基,并在50%甘油0.5mM EDTA中提供,以在-20℃下储存。

Overview


Haematologic Technologies, Inc. (HTI), an ISO 9001:2015 registered company, is a primary manufacturer that specializes in the isolation and characterization of high quality, plasma proteins which are intended for in vitro research use. HTI’s emphasis is focused on proteins involved in the coagulation cascade, as well as the regulation of bone metabolism. The HTI product line consists of over 150 highly purified and well-characterized proteins including zymogens, enzymes, cofactors, and inhibitors as well as a complementary line of monoclonal and polyclonal antibodies. Also available are factor deficient plasmas and customized, blood collection tubes made-to-order for clinical research. Services available include custom protein purification, protein modification, assay development, contract manufacturing and contract research. Please view our 3-minute video above.

Mission

The mission of Haematologic Technologies, Inc. is to supply the international coagulation research community with the highest quality proteins and reagents attainable. We strive to make continuous advancements in our manufacturing and quality control processes to ensure the superiority of our products to those of our competitors. HTI also endeavors to be on the cutting edge of coagulation research through in-house efforts and the formation of strategic relationships with firms at the top of thrombosis and hemostasis research.

Differentiation

Haematologic Technologies differentiates itself from its competitors by three main factors: excellent technical service, intellectual resources and custom manufacturing and research. HTI’s marquee difference is its technical service department, which strives to give customers unparalleled service for our products and their uses. When customers and distributors call with technical concerns, they can speak to a Ph.D. scientist that is actually involved with the manufacture of the product. Often, our technical service personnel go above and beyond the expected to provide customers with recommendations for their experimental problems, experimental design and procedural assistance. HTI feels that this type of relationship with its customers is the key to our success, and we will always provide this level of service to any of our customers. What’s more, HTI’s consultants are always at hand to provide an extra level of assistance if needed.

Quality Policy

"HTI is committed to achieving the highest level of customer satisfaction, and to the continual improvement of its products, services and quality management system." For a copy of our ISO certificate please click here.

Coagulation Products


  • Human Proteins
  • Human Zymogens

    Factor VII

    Factor IX

    Factor X

    Factor XI

    Factor XII

    Factor XIII

    Plasminogen

    Protein C

    Prothrombin

    Human Enzymes

    Activated Protein C

    Thrombin (alpha)

    Thrombin (beta, gamma)

    Factor VIIa

    Factor IXa

    Factor Xa

    Factor XIa

    Factor XIIIa

    Plasmin

    Human Cofactors

    Factor V

    Factor Va

    Fibronectin

    Protein S

    von Willebrand Factor

    Protein Z

    Human Protease Inhibitors

    Human Antithrombin III

    Heparin Cofactor II

    TAFI

    Angiostatin

    Alpha-2-Plasmin Inhibitor

    Human Platelet & Other Plasma Proteins

    Fibrinogen

    Beta-2-Glycoprotein 1

    Platelet Factor 4

    Beta-Thromboglobulin

    Thrombospondin

    Vitronectin

    Recombinant Tissue Factor

    Human Bone Related Proteins

    Osteocalcin

  • Bovine Proteins
  • Bovine Zymogens

    Factor IX

    Factor X

    Plasminogen

    Protein C

    Prothrombin

    Bovine Enzymes

    Activated Protein C

    Thrombin (alpha)

    Factor IXa

    Factor Xa

    Bovine Cofactors

    Factor V

    Factor Va

    Bovine Bone Related Proteins

    Osteonectin (SPARC)

    Osteocalcin

    New Bovine Products

    Lactadherin / MFG-E8

  • Mouse Proteins
  • Mouse Zymogens

    Factor X

    Plasminogen

    Prothrombin

    Mouse Enzymes

    Factor Xa

    Plasmin

    Other

    Human Antithrombin III

    Fibrinogen

  • Other Species
  • Rabbit

    Thrombomodulin

  • Snake Venom Proteases
  • Inhibitors
  • Other

    Corn Trypsin Inhibitor (CTI)

    DAPA

    Human Protease Inhibitors

    Human Antithrombin III

    Heparin Cofactor II

    TAFI

    Angiostatin

    Alpha-2-Plasmin Inhibitor

    Chloromethylketones

    Chloromethylketones

  • Fluorogenic Substrates
  • Antibodies
  • Factor Deficient Plasmas
  • Blood Collection Tubes
  • Custom Collection Tubes

    Custom Blood / Sample Collection Tubes

    Corn Trypsin Inhibitor Tubes

    Corn Trypsin Inhibitor Tubes

    Activated Clotting Time Tubes

    Activated Clotting Time Tubes




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