Smartox Biotechnology
我要查看Smartox Biotechnology产品信息：http://www.shijichina.com/goodsid/goodsview/19948370.html
Smartox Biotechnology
离子通道研究用多肽毒素的专业化生产商
Smartox Biotechnology是全球**一家专门生产动物毒液多肽毒素，用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。
Smartox Biotechnology于2009年由来自Grenoble神经科学研究所(Grenoble Institute of Neuroscience)的Michel de waard博士创立,Smartox Biotechnology专门研究动物毒液，制作合成多种毒液中的多肽成分（常称为毒素）。De Waard博士研究离子通道与毒素多肽的关系，尤其是鉴定、开发毒素多肽作为治疗性分子或细胞穿透肽(cell penetrating peptides, CPP)。其研究团队在毒液分离，药理性活性肽鉴定、富半胱氨酸肽定性、制作和优化等方面具有独特、丰富的经验。2010年，Smartox Biotechnolgy被法国研究部(Ministry of Research)授予“新兴企业OSEO奖(OSEO prize for emerging businesses)”。
总之，Smartox Biotechnology提供一系列高质量、具开创价值的多肽毒素。这些化合物在离子通道 研究中具有高的亲和性和选择性，是相应领域科学研究理想的生物毒素提供商和贴心的合作伙伴。
Smartox Biotechnology的毒素产品包括：
钠离子通道(Sodium channel)
|
Toxin name
|
Catalog #
|
Target
|
|
Phrixotoxin-3
|
13PHX003
|
Selective blocker of Nav1.2
|
|
µ-conotoxin GIIIB
|
CON020
|
Selective blocker of Nav1.4
|
|
µ-conotoxin CnIIIC
|
CON021
|
Selective blocker of Nav1.4
|
|
μ-conotoxin PIIIA
|
08CON006
|
Selective blocker of Nav1.4
|
|
Jingzhaotoxin-III
|
12JZH003
|
Selective blocker of Nav1.5
|
|
ProTx-II
|
07PTX002
|
Selective blocker of Nav1.7
|
|
ProTx-II Biotin
|
12PTB002
|
Selective blocker of Nav1.7
|
|
ProTx-I
|
12PTX001
|
Blocker of Nav1.8, Nav1.2, Nav1.5, Nav1.7
|
|
Huwentoxin-I
|
07HWT001
|
Blocker of TTX-S
|
|
Huwentoxin-IV
|
08HWT002
|
Blocker of TTX-S
|
|
Hainantoxin-III
|
13HTX003
|
Blocker of TTX-S
|
|
Hainantoxin-IV
|
12HTX001
|
Blocker of TTX-S
|
|
GsAF-I
|
12GSF001
|
Blocker of TTX-S
|
|
GsAF-II
|
12GSF002
|
Blocker of TTX-S
|
钾离子通道(Potassium channel)
|
KCa channels
|
|
Toxin name
|
Catalog #
|
Target
|
Description
|
|
Apamin
|
08APA001
|
SK1, SK2, SK3
|
|
|
Charybdotoxin
|
11CHA001
|
KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6
|
|
|
Iberiotoxin
|
12IBX001
|
KCa1.1
|
|
|
Leiurotoxin 1 (Scyllatoxin)
|
10LEI001
|
SK1, SK2, SK3
|
|
|
Tamapin
|
10TAM001
|
SK1, SK2, SK3
|
|
|
Kaliotoxin-1
|
08KTX002
|
BK, Kv1.1, Kv1.2, Kv1.3
|
|
|
|
|
Kv channels
|
|
ShK
|
08SHK001
|
Kv1.3, Kv1.1, Kv1.4, Kv1.6
|
|
|
TMR-ShK
|
SAT001
|
Kv1.3, Kv1.1
|
|
|
Margatoxin
|
08MAG001
|
Kv1.3
|
|
|
(Dap22)-ShK
|
13SHD001
|
Kv1.3
|
|
|
ADWX-1
|
13ADW001
|
Kv1.3
|
|
|
HsTx1
|
08NEU001
|
Kv1.3, Kv1.2
|
|
|
Agitoxin-2
|
13AGI002
|
Kv1.3, Kv1.1
|
|
|
Maurotoxin
|
08MAR001
|
Kv1.2, KCa3.1
|
|
|
Guangxitoxin 1E
|
11GUA002
|
Kv2.1, Kv2.2
|
|
|
Stromatoxin 1 NEW
|
SCT01
|
Kv2.1, Kv2.2
|
|
|
Kaliotoxin-1
|
08KTX002
|
BK, Kv1.1, Kv1.2, Kv1.3
|
|
|
Charybdotoxin
|
11CHA001
|
KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6
|
|
|
Phrixotoxin-2
|
PHX002
|
Kv4.2, Kv4.3
|
|
|
AmmTx3 NEW
|
AMX001
|
A-type potassium channels
|
|
|
|
|
Inwardly rectifying potassium channels
|
|
TertiapinQ
|
08TER001
|
Kir1.1, Kir3.1/3.4, Kir3.1/3.2-KCa1.1
|
|
|
|
|
hERG/Kv11.1
|
|
BeKm-1
|
13BEK001
|
ERG1
|
|
钙离子通道(Calcium channel)
|
High voltage-gated Ca2+ channels
|
|
Toxin name
|
Catalog#
|
Target
|
Description
|
|
ω-agatoxin IVA
|
11AGA001
|
P/Qtype
|
|
|
ω-Conotoxin MVIIC
|
08CON002
|
P/Qtype, N-type
|
|
|
ω-Conotoxin MVIIA
|
08CON001
|
N-type
|
|
|
ω-Conotoxin GVIA
|
08CON003
|
N-type
|
|
|
ω-Conotoxin SO3
|
08CON013
|
N-type
|
|
|
Huwentoxin I
|
07HWT001
|
N-type
|
|
|
ProTx-II
|
07PTX002
|
T-type, L-type
|
|
|
|
|
Intermediate voltage-gated Ca2+ channels
|
|
SNX482
|
08SNX002
|
R-type
|
|
|
|
|
Low voltage-gated Ca2+ channels
|
|
ProTx-I
|
12PTX001
|
T-type
|
|
|
ProTx-II
|
07PTX002
|
T-type, L-type
|
|
|
|
|
Ryanodine receptors
|
|
Maurocalcine
|
07PAU001
|
Ryr1
|
|
氯离子通道(Chloride channel)
|
Toxin name
|
Catalog #
|
Target
|
Description
|
|
Chlorotoxin
|
08CHL001
|
Blocker of small conductance Cl- channels
|
|
|
GaTx1
|
13GTX001
|
Selective blocker of CFTR channel
|
|
|
GaTx2
|
10GTX002
|
Selective blocker of ClC-2 channel
|
|
乙酰胆碱受体(Acetylcholine receptor)
|
Toxin name
|
Catalog #
|
Target
|
Description
|
|
α-conotoxin PeIA
|
13CON017
|
α9α10, α3β2 subunits
|
|
|
αC-Conotoxin PrXA
|
13CON016
|
α1/β1/ε/δ, α1/β1/γ/δ subunits
|
|
|
Waglerin-1
|
12WAG001
|
MusclenAChR
|
|
|
α-conotoxin MI
|
08CON012
|
α1/δsubunits
|
|
|
α-conotoxin GI
|
08CON005
|
α/δsite
|
|
|
α-conotoxin IMI
|
08CON011
|
α7 homomeric nAChR
|
|
|
α-conotoxin GID
|
CON019
|
Blocker of α3β2, α7 and α4β2 nAChRs
|
|
含N-甲基-D-天冬氨酸NR2B (NMDA, NR2B containing N-methyl-D-aspartate)
Conantokin-G选择性、特异性抑制含NR2B的NMDAR。Conantokin-G能剂量依赖性抑制Ca2+内流，抑制NMDA诱导的兴奋性中毒效应。研究表明，在小鼠皮层神经元，Conantokin-G阻滞NMDA引发的电流信号的IC50值为480 nM。
酸敏感离子通道(ASIC channel, Acid-Sensing Ion Channel)
|
Toxin name
|
Catalog #
|
Target
|
Description
|
|
APETx2
|
07APE002
|
Selective blocker of ASIC3
|
|
|
Psalmotoxin1/PcTx1
|
13PCT001
|
Selective blocker of ASIC1a
|
|
|
Ugr9-1
|
13UGR001
|
Blocker of ASIC3
|
|
瞬时受体电位(TRP channel, transient receptor potential)
|
Toxin name
|
Catalog #
|
Target
|
Description
|
|
GsMTx4
|
08GSM001
|
TRPC, TRPA
|
|
|
Vanillotoxin3
|
10VAN003
|
Activator of TRPV1
|
|
|
ProTx-I
|
12PTX001
|
Antagonist of TRPA1
|
|
嘌呤能通道(Purinergic channel)
Purotoxin-1
选择性抑制P2X3受体。100 nM Purotoxin-1 (PT-1)选择性抑制P2X3受体通道，在大鼠DRG神经元上，使用膜片钳实验表明：PT-1对电压门控通道和TRPV1均无抑制效应。10 µM ATP和100 µM α,β Methylene-ATP浓度下Purotoxin-1对P2X3受体有选择性作用，在该ATP浓度下Purotoxin-1对P2X2和杂化二聚体P2X2/3并无激动作用。
Purotoxin-1对疼痛的潜在治疗作用。
其它膜受体通道(Others)
Smartox Biotechnology还提供其他类型的膜受体抑制剂：
|
Toxin name
|
Catalog#
|
Target
|
|
Morphiceptin
|
011CAS001
|
Agonist of µ-opoid receptors
|
|
Lys-conopressin G
|
11CON14
|
Vasopressin-like peptide
|
|
GsMTx4
|
08GSM001
|
Mechano sensitive ion channels
|
|
Obtustatin
|
10OBT001
|
Blocks the binding of α1β1 integrin to collagen IV
|
|
Rho-Conotoxin TIA
|
CON022
|
Blocks α1-adrenergic receptor
|
